2,4-Difluorophenylboronic Acid CAS 144025-03-6: A Buyer’s Guide to Specifications, Uses, and Supply

2,4-Difluorophenylboronic acid, CAS 144025-03-6, is an aryl boronic acid used mainly as a building block in palladium-catalyzed Suzuki–Miyaura cross-coupling and related synthetic research. Its two fluorine substituents can help introduce a defined fluorinated aromatic fragment into pharmaceutical, agrochemical, and advanced organic synthesis programs. For purchasing, the most important checks are identity, assay, water content, residual solvents, packaging, documentation, and batch-to-batch consistency. At Maison Chemical, we help B2B buyers evaluate this material against their reaction, quality, regulatory, and delivery requirements before quotation.

Read more

Who This Guide Is For

This guide is intended for procurement teams, process chemists, R&D laboratories, contract manufacturers, and distributors sourcing 2,4-Difluorophenylboronic acid in commercial quantities. It is particularly useful when a buyer must compare more than a catalog name or a nominal purity value. The material may be needed for early-stage route discovery, process development, scale-up, or repeated manufacturing supply.

Buyers should use this information as a sourcing framework rather than as a substitute for a product-specific certificate of analysis or safety documentation. Exact commercial specifications can vary by supplier, grade, production route, and intended use. Before placing an order, I recommend confirming the current batch data, packaging configuration, and shipping requirements directly with the supplier.

Basic Chemical Context

2,4-Difluorophenylboronic acid contains a boronic acid group attached to a difluorinated aromatic ring. Its commonly used molecular formula is C₆H₅BF₂O₂, with a calculated molecular weight of approximately 157.91 g/mol. The CAS number, 144025-03-6, should be used together with the chemical name and structure when checking purchasing records, import documents, and internal substance databases.

As an aryl boronic acid, it participates in carbon–carbon bond-forming chemistry, especially Suzuki–Miyaura coupling with suitable aryl or vinyl halides under an appropriate catalytic system. The boronic acid group is the reactive handle, while the fluorine atoms remain part of the aromatic substituent in the desired product. Actual conversion depends on the reaction partners, catalyst, base, solvent, temperature, concentration, and handling conditions, so buyers should not treat the compound as universally compatible with every coupling process.

Specifications and Material Options

Identity and Core Specification Checks

A robust specification review begins with identity confirmation. The product name, CAS number, molecular formula, molecular weight, and structural representation should agree across the quotation, specification sheet, label, and certificate of analysis. For a routine research or synthesis grade, buyers commonly request an assay specification such as ≥98% or a higher internal target, but the acceptable threshold should be based on the customer’s process and analytical method rather than on a generic number alone.

Grade, Form, and Packaging Considerations

Commercial material is generally supplied as a solid, but appearance, particle size, and physical handling characteristics may differ between batches. These attributes can influence weighing, transfer, dissolution, and sampling, even when they are not the primary chemical specification. If the material will be used in automated or large-scale operations, the buyer should state any requirements for particle size, flowability, low dust, or defined packaging.

Packaging should be selected according to order size, storage duration, and the customer’s handling environment. Small research quantities may be suitable for tightly closed laboratory containers, while larger orders may require subdivided inner packaging to limit repeated exposure during use. I recommend asking for storage instructions and confirming whether the supplier uses moisture-protective packaging appropriate for the product’s handling needs.

Matching the Material to Its Application

Medicinal and Discovery Chemistry

In medicinal chemistry, this compound can serve as a fluorinated aromatic coupling partner for preparing analogues and screening compounds. Fluorine substitution is often used by chemists to modify molecular properties, but the effect depends on the complete molecular structure and cannot be predicted from the reagent name alone. Buyers should therefore evaluate the material according to the intended target synthesis, reaction scale, and purity sensitivity.

Process Development and Manufacturing

For process development, consistent assay, controlled impurities, reliable documentation, and repeatable delivery usually matter more than the lowest initial price. A process team may need additional information on analytical methods, lot traceability, residual solvents, metals, and packaging. If the compound is used repeatedly, the buyer should compare multiple lots or establish an incoming quality-control plan before approving routine supply.

Custom Synthesis and Research Services

Contract research organizations and custom synthesis laboratories may purchase this boronic acid for route scouting or client-specific intermediates. In this setting, a small trial quantity may be appropriate before a larger purchase commitment. The buyer should communicate whether the material is intended for feasibility work, a regulated development program, or a manufacturing route, because the required documentation and release criteria may differ.

Maison Chemical supply professional and honest service.

A Practical Supplier Selection Framework

Step 1: Define the Technical Requirement

Start by recording the CAS number, required quantity, target assay, acceptable impurity limits, packaging preference, and intended application. Include whether the process is sensitive to water, palladium-related impurities, residual solvents, or specific organic contaminants. A clear requirement prevents suppliers from quoting different material standards under the same product name.

Step 2: Verify Documents Before Comparing Price

Request a current specification sheet and a representative certificate of analysis. Depending on the project, useful documents may include a Safety Data Sheet, transport information, lot traceability, analytical method details, and a statement concerning residual solvents or elemental impurities. Documents should be reviewed for consistency with the exact CAS number and quoted grade, rather than accepted solely because the product title appears correct.

Step 3: Assess Supply and Commercial Terms

Ask suppliers to confirm available stock, production status, minimum order quantity, package sizes, estimated lead time, and quotation validity. Lead time is not a fixed chemical property and may change with inventory, batch scheduling, export procedures, and order volume. For planning purposes, buyers should obtain a written estimate in business days and confirm whether the quoted timeline applies to ready stock or new production.

Step 4: Review a Sample or Trial Lot

Where the application is technically important, a sample or small trial lot can help the laboratory verify identity, reaction performance, and handling behavior. The customer’s own analytical results should be compared with the supplier’s certificate using the same or appropriately qualified methods. This step is especially valuable before approving a long-term source or changing suppliers in an established process.

Pricing, MOQ, and Lead-Time Factors

The price of 2,4-Difluorophenylboronic acid may vary with purity, order quantity, packaging, production route, stock position, and documentation requirements. A lower unit price may not represent a lower total procurement cost if it is associated with a larger minimum order, longer lead time, or insufficient analytical support. Buyers should compare the complete commercial offer, including packaging, shipping terms, documentation, and any required testing.

Minimum order quantity should be matched to the project stage. Early discovery work may favor a small pack, while process development may justify a larger lot after the material has passed internal testing. Maison Chemical can review the requested quantity, destination, grade, and documentation needs to prepare a more relevant B2B quotation rather than offering a generic price without context.

Common Purchasing Mistakes

• Using only the chemical name without confirming CAS 144025-03-6 and the molecular structure.
• Comparing purity percentages without checking the analytical method and related-substance information.
• Ignoring water content or storage conditions when the planned reaction is moisture-sensitive.
• Accepting an estimated lead time without distinguishing ready stock from scheduled production.
• Ordering a large quantity before testing a representative lot in the intended reaction.

Another frequent mistake is assuming that every supplier’s “research grade” has the same meaning. Commercial labels are not always equivalent across companies, so the buyer should define measurable acceptance criteria. If a customer has a validated process, the supplier should be told which attributes are critical to quality and which are merely preferred.

How Maison Chemical Supports B2B Buyers

Maison Chemical supplies and exports organic boronic acids, including 2,4-Difluorophenylboronic acid CAS 144025-03-6, for customers evaluating research, development, and production requirements. We support quotation preparation by reviewing quantity, target specification, packaging, destination, and documentation expectations. Availability and lead time are confirmed case by case, because they depend on current inventory and the requested commercial conditions.

For a more efficient inquiry, send the CAS number, required quantity, target purity, application stage, destination country, preferred packaging, and requested documents. If you need a sample first, state the evaluation purpose and any special analytical requirements. This information allows us to recommend a practical supply option and identify questions that should be resolved before purchase.

Key Takeaways

• 2,4-Difluorophenylboronic acid CAS 144025-03-6 is an aryl boronic acid used mainly for fluorinated aromatic synthesis and cross-coupling research.
• Its calculated molecular weight is approximately 157.91 g/mol, while commercial assay targets such as ≥98% must be verified against the supplier’s current specification and method.
• Identity, assay, water, residual solvents, packaging, documentation, MOQ, and lead time should be reviewed together.
• A sample or trial lot is a sensible risk-control step before approving recurring or larger-volume supply.

Conclusion: The Best Next Step for Buyers

The right purchasing decision is not based on the product name or unit price alone. Buyers should first define the required grade, then verify analytical documents, assess packaging and storage, compare commercial terms, and test a representative lot when the application justifies it. This approach supports a more controlled and efficient sourcing decision for 2,4-Difluorophenylboronic acid CAS 144025-03-6.

To request a quotation from Maison Chemical, provide your quantity, specification, destination, packaging preference, and documentation requirements. We can then review the inquiry and respond with the applicable supply option, commercial terms, and next steps for sample evaluation or order placement.

If you want to learn more, please visit our website 2,4-Difluorophenylboronic acid CAS 144025-03-6.