Pyridine-3-boronic acid CAS 1692-25-7: Uses, Specifications, and Buying Guide

Pyridine-3-boronic acid, identified by CAS 1692-25-7, is a heteroaryl boronic acid used primarily as a building block in organic synthesis. Its principal value is the combination of a pyridine ring and a boronic acid group, which makes it suitable for palladium-catalyzed Suzuki–Miyaura coupling and related research applications. The commonly listed molecular formula is C₅H₆BNO₂, with a molecular weight of approximately 122.92 g/mol. At Maison Chemical, I help buyers evaluate identity, quality requirements, packaging, and supply conditions before placing an inquiry.

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Who This Guide Is For

This guide is intended for pharmaceutical and agrochemical research teams, medicinal chemistry laboratories, contract research organizations, university laboratories, and chemical distributors. It is also useful for procurement specialists who need to compare technical specifications before requesting a quotation. Because commercial requirements differ between discovery-scale experiments and process development, I recommend treating the information below as a purchasing framework rather than as a substitute for a project-specific specification.

Buyers should confirm the required grade, quantity, analytical documentation, packaging format, and delivery destination before ordering. A small research request may prioritize availability and analytical data, while a larger development program may require tighter impurity controls, repeatable production, and a documented change-notification process. These factors can affect the practical suitability of the same CAS-numbered product.

Basic Chemical Context

Pyridine-3-boronic acid contains a six-membered aromatic pyridine ring with the boronic acid substituent located at the 3-position. The boronic acid functionality can participate in carbon–carbon bond-forming reactions, especially when paired with an appropriate aryl or vinyl halide and a palladium catalyst. The pyridine nitrogen also provides a useful heteroaromatic feature for tuning the electronic and binding properties of synthesized molecules.

The compound’s reference identifiers are important during sourcing. The CAS number is 1692-25-7, the molecular formula is C₅H₆BNO₂, and the approximate molecular weight is 122.92 g/mol. Buyers should still compare the supplier’s certificate of analysis, product label, and safety documentation because naming conventions, hydration state, residual solvent profile, and analytical methods can influence how the material is specified.

Uses and Application Matching

Suzuki–Miyaura Coupling

The most recognized use of Pyridine-3-boronic acid is as a coupling partner in Suzuki–Miyaura chemistry. In a typical reaction design, the boronic acid group reacts with an aryl, heteroaryl, or vinyl halide to form a new carbon–carbon bond. This allows chemists to introduce a pyridinyl fragment into a more complex molecular scaffold.

Reaction performance depends on more than the CAS number. Catalyst selection, base, solvent, temperature, reaction concentration, substrate electronics, and the stability of the boronic acid can all affect conversion and selectivity. For that reason, I recommend testing a small representative reaction before committing to a larger quantity.

Medicinal and Heterocyclic Chemistry

Pyridine-containing fragments are common in medicinal chemistry because the ring can contribute polarity, hydrogen-bond acceptance, and specific electronic characteristics. Pyridine-3-boronic acid can therefore serve as an intermediate for preparing compound libraries and analog series. Its usefulness is especially relevant when researchers want to vary a core scaffold through modular cross-coupling.

In discovery work, the material may be used in milligram- or gram-scale synthesis, while process research may require a larger and more consistent supply. The appropriate purchase grade should reflect the downstream application, analytical sensitivity, and impurity tolerance of the project.

Agrochemical and Advanced Organic Synthesis

Heteroaryl boronic acids can also be used in the preparation of research intermediates for agrochemical and specialty chemical programs. The compound is not itself a finished active ingredient; rather, it is a synthetic input that may help construct more complex molecules. Any proposed application should be reviewed against the customer’s reaction route, regulatory obligations, and laboratory safety procedures.

Types, Material Options, and Specifications

For most buyers, the key material distinction is not a different chemical identity but the commercial grade and documentation package. A research-grade product may be appropriate for route scouting, whereas a project requiring reproducible impurity control may call for a more detailed specification and lot-release testing. Packaging can also vary from small laboratory quantities to larger containers selected according to order size and handling requirements.

I advise buyers not to rely on an advertised assay number alone. The analytical method, related substances, water or solvent content, residual metals, and result basis may be equally important for a sensitive synthesis. If the material will enter a regulated development workflow, the customer should define acceptance criteria before quotation rather than after delivery.

How to Select the Right Product

Step 1: Define the Intended Reaction

Start by identifying how Pyridine-3-boronic acid will be used. Record the reaction type, expected scale, target conversion, and whether the product will be used for screening, intermediate synthesis, process development, or another purpose. This information helps determine whether a general research specification is sufficient or whether additional impurity and documentation requirements are necessary.

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Step 2: Set the Quality Requirements

Specify the required assay, analytical method, impurity limits, water content, residual solvent expectations, and packaging conditions where relevant. If the customer has an internal specification, I recommend sharing it during the inquiry stage. This allows the supplier to confirm feasibility instead of offering a product that is technically similar but unsuitable for the process.

Step 3: Confirm Quantity and Delivery Conditions

Quantity should be based on the planned experiments, expected process losses, repeat reactions, and contingency needs. Buyers should ask whether the quoted quantity is available from current stock or will require production. Lead time is not universal; it can vary with order size, quality review, packaging, export documentation, and destination.

Step 4: Review the Documentation

Before purchasing, request a current certificate of analysis, safety data sheet, product specification, and available batch information. The COA should identify the lot and show the tests actually performed for that lot. For international shipments, buyers should also confirm labeling, customs information, and the documentation required by the receiving country.

Pricing, MOQ, and Lead-Time Considerations

The price of Pyridine-3-boronic acid can change according to quantity, specification, packaging, production route, availability, and destination. A small laboratory pack may have a higher unit cost than a larger commercial quantity because packaging and handling costs are distributed over fewer grams. I recommend requesting tiered pricing when the project has a realistic scale-up path.

Minimum order quantity is supplier- and product-dependent. Rather than assuming a fixed MOQ, buyers should state the desired quantity and ask whether a sample, trial quantity, or production batch is available. A practical inquiry should include the target quantity in grams or kilograms, required delivery date, destination, grade, and documentation needs.

Lead time should be treated as a quotation item, not as a permanent product characteristic. Stock availability may support a shorter dispatch schedule, while made-to-order material may require additional production and quality-control time. For projects with fixed experimental windows, I suggest confirming the shipping schedule in writing and allowing time for import clearance and receiving inspection.

Supplier Evaluation Checklist

A reliable supplier should be able to identify the product consistently by name, CAS number, molecular formula, and lot documentation. The supplier should also communicate clearly about available quantities, storage recommendations, packaging, transport conditions, and any known limitations in the specification. These details are more useful than broad claims about quality that are not connected to a defined test method.

• Confirm product identity and CAS 1692-25-7.
• Request the current specification and lot-specific certificate of analysis.
• Review assay, related substances, water or solvent content, and residual metal requirements when relevant.
• Ask whether the quoted material is in stock or scheduled for production.
• Confirm package size, labeling, storage conditions, and transport documentation.
• Discuss sample availability before a larger purchase if the reaction is untested.
• Clarify MOQ, lead time, payment terms, and destination-specific shipping requirements.

Common Buying Mistakes

One common mistake is selecting solely by the lowest price without comparing assay basis, documentation, or delivery conditions. Another is assuming that all boronic acids behave identically in storage and coupling reactions. Buyers should evaluate the supplier’s handling guidance and, where necessary, conduct incoming quality checks before using the material in a critical route.

It is also risky to postpone specification discussions until after the purchase order is issued. If the project requires a particular impurity profile, packaging format, or analytical method, those requirements should be included in the initial request for quotation. Clear communication reduces the possibility of receiving a material that meets the product name but not the process need.

How Maison Chemical Supports Buyers

At Maison Chemical, I approach Pyridine-3-boronic acid sourcing as a technical and commercial evaluation rather than a simple product lookup. We can discuss the intended application, quantity, target specification, packaging preference, and destination before preparing a quotation. Where applicable, we can provide available product documentation for customer review and help clarify which requirements should be confirmed with the selected batch.

Our support is designed for research buyers, distributors, and industrial procurement teams that need a clear path from product identification to delivery. I recommend sending the CAS number, required quantity, target grade, delivery location, and any internal specification in your inquiry. This gives our team the information needed to respond with a more relevant supply option and realistic commercial terms.

Key Takeaways

• Pyridine-3-boronic acid CAS 1692-25-7 is a heteroaryl boronic acid used mainly in cross-coupling and intermediate synthesis.
• Its commonly listed formula is C₅H₆BNO₂, with an approximate molecular weight of 122.92 g/mol.
• Product suitability depends on assay, impurity profile, documentation, packaging, quantity, and application requirements.
• MOQ, price, stock status, and lead time should be confirmed for each order rather than assumed.
• A clear inquiry containing the CAS number, quantity, grade, destination, and specification is the best next step.

Conclusion and Next Steps

Pyridine-3-boronic acid CAS 1692-25-7 is a practical building block for introducing a pyridinyl group into more complex molecules, particularly through Suzuki–Miyaura coupling. The right purchasing decision depends not only on chemical identity but also on the required quality level, analytical evidence, quantity, packaging, and delivery plan. Buyers should therefore compare complete specifications and lot documentation instead of relying on product name or price alone.

To begin, prepare your target quantity, application, required assay or impurity limits, delivery destination, and preferred timeline. Send these details to Maison Chemical for a product and supply review. I can then help you evaluate the available specification, documentation, MOQ, pricing basis, and lead-time expectations before you proceed with an order.

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