Pyridine-3-boronic Acid CAS 1692-25-7: Properties, Uses, and Buying Guide

Pyridine-3-boronic acid (CAS 1692-25-7), also called 3-pyridylboronic acid or pyridin-3-ylboronic acid, is a heteroaryl boronic acid used primarily as a building block in palladium-catalyzed Suzuki–Miyaura cross-coupling. Its pyridine ring and boronic acid group let chemists introduce a pyridyl fragment into more complex molecules. Buyers should confirm identity, assay, packaging, documentation, and availability for the specific batch before ordering, because commercial specifications and lead times can vary by supplier.

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Key Takeaways

• CAS number: 1692-25-7; molecular formula: C₅H₆BNO₂; molecular weight: approximately 122.92 g/mol.
• Its principal synthetic role is as a pyridyl coupling partner, especially in Suzuki–Miyaura chemistry.
• Reaction performance depends on the coupling partner, catalyst, solvent, base, and conditions; validate it in the intended process.
• Request a current specification and batch-specific documentation, and confirm price, minimum order quantity, and shipping schedule before purchase.

Who This Guide Is For

This guide is intended for procurement teams, medicinal and process chemists, contract manufacturers, and distributors assessing Pyridine-3-boronic acid for research or production use. It explains the compound’s identity and typical role, then outlines practical checks for supplier evaluation. It does not replace a current product specification, safety data sheet, or process-specific laboratory assessment.

Basic Identity and Chemical Context

What Pyridine-3-boronic Acid Is

Pyridine-3-boronic acid is an organoboron compound in which a boronic acid group, –B(OH)₂, is attached at the 3-position of a pyridine ring. The pyridine nitrogen is part of the aromatic heterocycle, while the boron-containing group provides a handle for carbon–carbon bond formation. This combination makes the compound useful when a synthesis calls for installation of a 3-pyridyl unit.

Its molecular formula is C₅H₆BNO₂, and its calculated molecular weight is about 122.92 g/mol. For stoichiometric planning, 1 mmol of the anhydrous compound corresponds to approximately 122.92 mg before adjustment for assay or other batch-specific factors. Check the supplier’s stated assay and material form when calculating actual charge quantities.

Properties Buyers Should Confirm

CAS 1692-25-7 is the key identifier to use when requesting a quotation, but identity alone does not establish the grade or quality needed for a particular application. Confirm the product name, formula, assay or purity method, appearance, and any stated limits for relevant impurities against the current specification. Physical appearance and storage recommendations should be taken from the supplier’s product documents rather than assumed from the chemical name.

Like other boronic acids, this material may show condition-dependent behavior during storage or reaction, including sensitivity to moisture or transformations such as protodeboronation under some conditions. The extent of any change depends on factors such as solvent, pH, temperature, and time. For a critical synthesis, evaluate the material under the intended conditions and follow the handling guidance provided with the batch.

Uses and Application Matching

Suzuki–Miyaura Coupling

The most established synthetic role for Pyridine-3-boronic acid is as a coupling partner with an appropriate aryl or vinyl electrophile in Suzuki–Miyaura cross-coupling. The reaction can form a carbon–carbon bond that incorporates the pyridyl group into a target molecule. Researchers commonly assess catalyst, base, solvent, and temperature as a system rather than treating the boronic acid as the only determinant of yield or selectivity.

This building-block role may be relevant to medicinal chemistry, heteroaromatic compound synthesis, and development of intermediates for further research. However, the suitability of this specific reagent depends on the target structure and route. If the substrate is sensitive or the process is intended for scale-up, confirm compatibility through route-specific testing rather than relying on a general reaction description.

Matching the Material to the Project

For exploratory research, a buyer may prioritize availability, practical pack size, and documentation suitable for laboratory use. For a process-development or manufacturing program, additional considerations may include impurity profile, lot consistency, packaging, and the supplier’s ability to confirm future availability. In each case, ask the supplier to state which specifications are guaranteed and which are informational.

If your synthesis requires a different pyridyl substitution pattern or a protected boron reagent, compare the requested structure carefully before purchasing. Positional isomers and related organoboron compounds are not interchangeable by name alone. Include the CAS number and, where possible, a structure or exact product name in the request to reduce identification errors.

Buyer Selection Framework

1. Verify Identity and Documentation

Start by matching the product name and CAS number on the quotation, specification, label, and shipping documents. Request a current certificate of analysis for the available lot and review the stated test methods and results. Also request the safety data sheet and handling information needed by your organization.

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2. Define Quality and Quantity Requirements

Specify the assay or purity requirement that your chemistry and quality system actually need. Do not assume that a general listing or catalog description guarantees a particular test method or impurity limit. If your project has restricted-substance, analytical, or customer-specific requirements, communicate them before the order is confirmed.

For scale planning, translate the reaction requirement into a requested quantity and include a realistic allowance for evaluation or repeat work. As illustrative inquiry quantities, buyers might request quotes for 1 g, 25 g, or 100 g; these examples are not a statement of stock or standard pack sizes. Ask the supplier which pack options are currently available and whether the offered quantity comes from one lot.

3. Assess Supply and Commercial Terms

Price, minimum order quantity, and lead time can depend on stock status, order size, packaging, destination, and required documentation. Obtain these terms in a written quotation instead of assuming they are fixed across orders. For time-sensitive work, ask whether the quoted schedule includes dispatch only or delivery to the named destination.

Before committing, clarify packaging suitability, shipping conditions, document availability, and how changes to specification or quantity may affect the schedule. For larger or recurring requirements, discuss forecast volumes and the possibility of coordinating supply across project stages. These checks help buyers compare offers on more than unit price alone.

Supplier Evaluation Checklist

A suitable supplier should be able to respond clearly to questions about identity, batch documentation, commercial terms, and delivery. Evaluate the evidence provided for the specific offered lot rather than relying only on broad claims about product quality. A straightforward qualification process also makes it easier to identify gaps before purchase.

• Does the quotation identify Pyridine-3-boronic acid and CAS 1692-25-7 clearly?
• Can the supplier provide the current specification, batch-specific certificate of analysis, and safety data sheet?
• Are assay, test methods, pack size, and any requested impurity limits stated clearly?
• Are price, minimum order quantity, lead time, shipping terms, and documentation included in writing?
• Can the supplier discuss the expected supply path for repeat or larger-volume orders without making unsupported guarantees?

Common Purchasing Mistakes to Avoid

One frequent mistake is ordering based on a product name without checking the CAS number and substitution position. Another is treating a listed purity value as a complete description of quality without reviewing the analytical method, batch data, and relevant impurities. Buyers can also create avoidable delays by requesting specialized documents only after an order has been placed.

Do not assume that a reagent’s performance in one literature procedure will transfer directly to another substrate or scale. Catalyst loading, base, solvent, reaction time, and temperature can all influence the outcome, and the boronic acid may not be the only variable. Plan an appropriate evaluation and follow the supplier’s handling instructions for the material received.

Working with Maison Chemical

Maison Chemical supplies Pyridine-3-boronic acid CAS 1692-25-7 for B2B buyers seeking a clearly identified heteroaromatic building block. We recommend sharing your required quantity, target specification, destination, and documentation needs when requesting a quotation. This allows our team to check the relevant commercial and product details for the requested order rather than relying on assumptions.

For a current offer, ask Maison Chemical to confirm available pack options, lot-specific documentation, price, minimum order quantity, and estimated lead time. If your project has a specific assay, impurity, or packaging requirement, include it in the initial inquiry so it can be reviewed before order confirmation. Any supply commitment should be based on the written quotation and confirmed batch documents.

Conclusion: Choosing and Buying Pyridine-3-boronic Acid

Pyridine-3-boronic acid (CAS 1692-25-7) is a 3-pyridyl organoboron building block used chiefly in Suzuki–Miyaura coupling. Its formula, C₅H₆BNO₂, and molecular weight of approximately 122.92 g/mol support identification and reaction planning, but they do not establish a specific commercial grade or guarantee reaction performance. The right buying decision depends on matching the offered lot’s documentation and specification to your application.

As a practical next step, prepare your target quantity, required assay or other quality criteria, destination, and document needs, then request a written quotation and current batch information. Maison Chemical can review the inquiry and confirm the applicable product and supply details. This approach gives your procurement and technical teams a clear basis for evaluating the material before placing an order.