What Is 4-(Hydroxymethyl)phenylboronic Acid CAS 59016-93-2? Uses, Properties, and Specifications

4-(Hydroxymethyl)phenylboronic acid, CAS 59016-93-2, is an aromatic boronic acid with a hydroxymethyl group positioned para to the boronic acid group on a benzene ring. Its molecular formula is C₇H₉BO₃, and its molecular weight is approximately 151.96 g/mol. Researchers and process chemists commonly consider it as an aryl building block for cross-coupling chemistry, while the hydroxymethyl group offers a second functional handle for further synthesis. At Maison Chemical, we support B2B inquiries by helping buyers confirm product identity, requested specifications, documentation, and supply requirements before an order.

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Key Takeaways

• CAS 59016-93-2 identifies 4-(Hydroxymethyl)phenylboronic acid, a bifunctional aromatic building block.
• The boronic acid group can be used in suitable carbon–carbon coupling reactions; the benzylic alcohol can provide a separate point for chemical modification.
• Purity, appearance, water content, residual solvents, packaging, and documentation should be confirmed for the specific batch rather than assumed from the compound name.
• For procurement, share the intended application, target quantity, destination, and required analytical documents so a supplier can assess fit and availability.

Identity and Chemical Structure

The compound consists of a phenyl ring bearing two substituents: a boronic acid group and a hydroxymethyl group. The substituents occupy para, or 1,4, positions on the ring. This arrangement makes the molecule useful to consider when a synthesis requires an aromatic coupling partner that also retains an alcohol functionality.

The formula and molecular weight are useful for checking that a quotation, specification sheet, or internal material record refers to the intended substance. The CAS number is a practical identifier, but it should not be the only check when approving a chemical for use. Buyers should also compare the product name, formula, analytical identification, and batch documentation.

Core Functions in Synthesis

Arylboronic Acid as a Coupling Partner

Arylboronic acids are widely used as organoboron reagents in Suzuki–Miyaura cross-coupling, a reaction class used to form carbon–carbon bonds between suitable coupling partners. In this compound, the aryl group is the part transferred into the product under an appropriate reaction system. The outcome depends on the substrate, catalyst, base, solvent, and reaction conditions, so this material should not be treated as a guarantee of a particular yield or process performance.

For route planning, chemists generally assess whether the desired product requires the para-substituted aromatic ring and whether the boronic acid is compatible with the other functional groups in the reaction. A small-scale evaluation may be appropriate when moving into a new substrate or process. Reaction conditions should be selected and validated by the project’s qualified chemists.

Hydroxymethyl Group as a Secondary Handle

The hydroxymethyl substituent is a primary alcohol attached to the aromatic ring through a methylene group. Depending on the target molecule and route, an alcohol may be retained, protected, or transformed into another functional group. This gives the building block potential value in multistep synthesis, although compatibility and selectivity must be checked for each route.

The combination of an arylboronic acid and an alcohol can be useful when a project needs more than one point of functionalization. It may also introduce additional planning considerations, such as whether the alcohol needs protection during coupling or later reaction steps. These decisions depend on the complete molecular structure and the selected chemistry.

Application Scenarios

• Medicinal and discovery chemistry: As a building block for preparing substituted biaryl or related aromatic compounds during compound synthesis and route exploration.
• Fine chemical synthesis: As a starting material where a para-hydroxymethyl-substituted aryl unit is part of the intended molecular structure.
• Intermediate development: For projects that may use the boronic acid group for coupling and subsequently modify or retain the alcohol group.
• Process research: For chemists evaluating a specific arylation route, subject to validation of reaction conditions, scale, and impurity control.

These are chemistry-based use cases, not a claim that the product is approved for a specific end use or suitable for every process. Before purchase, buyers should confirm that the material’s grade, analytical profile, and handling requirements fit their intended application. The product should be evaluated within the buyer’s own quality and safety procedures.

Types and Material Options

The name and CAS number identify the target chemical, but commercial offerings may differ in grade, assay, packaging, and available documentation. A buyer may need research or synthesis-grade material for laboratory evaluation, while process development may require tighter control of specified impurities or a larger, consistent supply. These distinctions should be discussed directly with the supplier rather than inferred from a product name alone.

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Also clarify whether the requested material must meet a particular internal specification, whether the buyer will accept supplier standard specifications, and whether any special packaging or shipping conditions apply. If the material is being evaluated for a regulated or highly controlled workflow, confirm required documents and qualification steps before placing an order. Availability, lead time, and pack sizes should be confirmed for the requested quantity and destination.

Key Specifications to Review

A specification should help establish both identity and suitability for the intended process. Buyers can request that the supplier clarify the test methods and reporting basis for each parameter, rather than relying on an unqualified headline purity value. The following items are commonly useful points to review for a specialty organic intermediate:

• Identity: Confirm the product name, CAS number, and an appropriate analytical identification method, such as NMR or another method stated in the batch documentation.
• Assay or purity: Review the reported value in %, its test method, and whether the result is stated on an as-is or corrected basis.
• Water content: Where relevant to the reaction or handling plan, ask whether water is measured and reported in %.
• Residual solvents: For process-sensitive use, ask which solvents are tested and whether results are reported in ppm.
• Appearance and packaging: Confirm the described physical appearance, container type, net quantity, and any handling instructions supplied for the batch.
• Documentation: Establish whether a Certificate of Analysis (COA), Safety Data Sheet (SDS), and other requested records are available for the offered material.

These are specification topics to discuss, not guaranteed values for every lot of CAS 59016-93-2. Numerical acceptance limits should be agreed between buyer and supplier before purchase, especially when the material will enter a validated process. If a particular impurity or analytical method is critical, identify it explicitly in the inquiry.

Buyer Selection Factors

Match the Material to the Route

Start with the reaction and downstream steps, not just the compound name. Consider whether the boronic acid functionality is required, whether the hydroxymethyl group must remain unprotected, and whether either group could interfere with other reagents or intermediates. Where uncertainty remains, discuss evaluation quantities and analytical checks with the project team and supplier.

Confirm Commercial and Quality Requirements

Before issuing a purchase order, align on required quantity, target specification, packaging, destination, and requested delivery window. Ask what batch-specific records will be supplied and whether the supplier can address any customer quality questionnaire or documentation request. For repeat purchasing, it is useful to agree in advance how specification changes, batch variation, and requalification will be handled.

Supplier Support from Maison Chemical

Maison Chemical supports B2B sourcing inquiries for 4-(Hydroxymethyl)phenylboronic acid CAS 59016-93-2. We can review the requested grade, quantity, destination, and specification requirements to help determine whether the available offer aligns with your project needs. Product availability, lead time, packaging, and document availability should be confirmed for each inquiry and order.

To help us respond efficiently, include the CAS number, requested quantity, intended application or grade, destination country, and any required assay, impurity, or documentation criteria. If your organization uses a supplier qualification process, mention the documents needed at the quotation stage. This allows the supply discussion to focus on the details that matter for your procurement and technical review.

Conclusion and Next Steps

4-(Hydroxymethyl)phenylboronic acid is a para-substituted aromatic boronic acid with formula C₇H₉BO₃ and a molecular weight of approximately 151.96 g/mol. Its boronic acid group makes it a potential coupling partner in suitable synthesis routes, while its hydroxymethyl group provides an additional functional handle. Its suitability depends on the specific chemistry, grade, batch specification, and handling requirements.

For a sourcing decision, first verify identity and define the analytical limits your process requires. Then request batch-specific documentation, confirm packaging and delivery details, and assess the material against your own technical and quality criteria. Contact Maison Chemical with your target quantity and specification needs to discuss a B2B quotation and supply options.

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