What Is 1,4-Cyclohexanedione Monoethylene Acetal CAS 4746-97-8? Uses, Specifications, and Buying Considerations

1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 is a protected cyclohexanedione intermediate used primarily in organic synthesis, pharmaceutical research, and specialty chemical development. It is commonly described as a mono-ketal derivative of 1,4-cyclohexanedione, in which one ketone group is protected with an ethylene glycol unit while the other carbonyl remains available for further reactions. At Maison Chemical, I supply this material for B2B customers who need a defined identity, controlled quality, and practical export support.

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The commonly associated molecular formula is C₈H₁₂O₃, with a calculated molecular weight of approximately 156.18 g/mol. CAS 4746-97-8 identifies the substance, but a purchasing decision should also consider assay, water content, appearance, analytical data, packaging, and batch consistency. Because final specifications can vary by supplier and application, I recommend confirming the current product specification and certificate of analysis before placing an order.

What Is 1,4-Cyclohexanedione Monoethylene Acetal?

This compound is a cyclic ketal-protected cyclohexanedione intermediate. The ethylene acetal protects one carbonyl group, reducing its immediate reactivity during selected synthesis steps, while the unprotected ketone can remain available for transformations such as condensation, reduction, substitution, or other carbonyl chemistry. This selective protection can help chemists control reaction order and reduce unwanted reactions at the protected site.

In chemical catalogues and technical discussions, the material may also be associated with names such as 1,4-dioxaspiro[4.5]decan-8-one or a related systematic designation. Buyers should compare the product name, CAS number, molecular formula, structure, and analytical data rather than relying on a trade name alone. I also advise customers to confirm whether their internal documentation requires a particular nomenclature convention.

Core Functions and Chemical Value

Selective carbonyl protection

The primary function of the ethylene acetal is to temporarily mask one ketone group. This gives synthetic chemists greater control when a reaction must be performed at the remaining carbonyl or elsewhere in the molecule. The acetal is generally intended to remain stable through selected reaction conditions and can later be removed under suitable acidic hydrolysis conditions, although the exact compatibility depends on the complete reaction system.

Versatile intermediate platform

The molecule combines a protected ketone with a second reactive ketone in a compact cyclic structure. This makes it useful as a building block for preparing more complex intermediates, substituted cyclohexanones, heterocyclic compounds, and research compounds. The correct reaction pathway depends on catalyst, solvent, temperature, acidity, and the intended downstream product, so I recommend process validation at laboratory scale before commercial use.

Typical Application Scenarios

CAS 4746-97-8 is mainly relevant to customers working in pharmaceutical intermediate synthesis, medicinal chemistry, process research, and specialty organic synthesis. It may be used when a protected cyclohexanone structure is required for sequential functionalization. Research organizations may also evaluate it during route scouting, impurity studies, or the development of new synthetic pathways.

Its value is not limited to one final product category. Depending on the route, the intermediate can support the preparation of more highly functionalized cyclic compounds and other building blocks used in pharmaceutical or advanced chemical research. Since published applications do not automatically establish suitability for every process, buyers should assess reaction performance using their own validated conditions.

Types and Material Options Buyers May Encounter

Suppliers may offer this compound in different commercial grades, package sizes, or specification levels rather than as fundamentally different chemical types. The most important distinction is usually between research or development material and production-oriented material supported by a consistent specification and batch documentation. Some buyers may also request a customized package, additional testing, or a tighter internal limit for a critical impurity.

For a routine synthesis, a standard commercial grade may be sufficient if the assay and impurity profile meet process requirements. For regulated or highly sensitive development work, customers may need stronger traceability, defined analytical methods, and retained samples. I help buyers match the documentation level to the intended use instead of automatically selecting the most expensive option.

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Key Specifications to Review

A specification sheet should confirm the product identity and the quality attributes relevant to the intended synthesis. Common review items include appearance, assay, related substances, water content, residual solvents, and analytical identification. Depending on the customer’s quality system, a certificate of analysis may include HPLC, GC, NMR, infrared testing, or other agreed methods.

For orientation, the molecular weight is approximately 156.18 g/mol, and the molecular formula is commonly listed as C₈H₁₂O₃. These are useful identity checks, but they do not replace lot-specific testing. I recommend treating a supplier’s current COA as the controlling document for each shipment.

How B2B Buyers Should Select the Material

Start with the downstream reaction

First, I ask what the customer intends to do with the intermediate. A material used for route screening may require a different documentation package from one entering a scale-up or regulated development process. The reaction conditions also help determine whether water, residual solvent, color, or a particular impurity needs tighter control.

Review quality evidence before price

Price is important, but a low unit cost can become uneconomical if inconsistent quality causes failed reactions, additional purification, or production delays. Buyers should request a recent COA, product specification, representative analytical data, and clarification of the test methods. If the material is critical to a long synthesis, I also recommend discussing batch-to-batch consistency and sample approval in advance.

Confirm packaging, MOQ, and delivery expectations

Minimum order quantity, available inventory, production scheduling, and export documentation can affect the total sourcing cost. Lead time should be confirmed for the actual requested quantity rather than assumed from a small sample offer. I can review package size, shipment destination, required documents, and planned consumption so the quotation reflects the real purchasing situation.

Supplier Support from Maison Chemical

At Maison Chemical, I support customers as a manufacturer, supplier, and exporter of chemical intermediates, including 1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8. My role is to help clarify product identity, align the specification with the customer’s application, and provide practical information for technical and procurement review. I avoid treating a catalogue description as a substitute for project-specific communication.

For an initial inquiry, customers can provide the required quantity, target assay or impurity limits, intended application, packaging preference, destination country, and desired delivery schedule. I can then confirm current availability, applicable documentation, sample options, and quotation conditions. Where a customer has an internal specification, I recommend sending it for comparison before order confirmation.

Key Takeaways

• 1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 is a protected cyclohexanedione intermediate used in controlled organic synthesis.
• Its commonly associated molecular formula is C₈H₁₂O₃, with an approximate molecular weight of 156.18 g/mol.
• The ethylene acetal protects one carbonyl while leaving another ketone available for further chemical transformation.
• Important purchasing factors include identity, assay, impurities, water, residual solvents, packaging, documentation, MOQ, and lead time.
• A current lot-specific COA and an agreed specification should guide the final buying decision.

Conclusion: Is This the Right Intermediate for Your Project?

1,4-Cyclohexanedione monoethylene acetal CAS 4746-97-8 is a useful choice when your synthesis requires a selectively protected cyclohexanedione building block. Its practical value comes from combining carbonyl protection with an available ketone for subsequent functionalization. However, suitability depends on your reaction conditions, impurity tolerance, documentation requirements, and scale.

As the next step, I recommend comparing your internal specification with the supplier’s current COA, confirming the intended quantity and packaging, and requesting a sample when process validation is necessary. Contact Maison Chemical with your target specification, application, quantity, and destination, and I will help you evaluate supply feasibility and prepare a B2B quotation based on your actual requirements.

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