What Is 4-Benzyloxy-2-methylphenylboronic Acid CAS 847560-49-0? Uses, Specifications, and Sourcing

4-Benzyloxy-2-methylphenylboronic acid, identified by CAS 847560-49-0, is an aryl boronic acid used primarily as a synthetic building block in research and development. Its boronic acid group can participate in carbon–carbon bond-forming reactions, while the benzyloxy and methyl substituents provide a defined substitution pattern for medicinal chemistry and advanced organic synthesis. At Maison Chemical, we help B2B buyers evaluate this intermediate according to identity, purity, documentation, quantity, and intended reaction use rather than relying on a product name alone.

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The compound is generally represented by the molecular formula C₁₄H₁₅BO₃, with a calculated molecular weight of approximately 242.08 g/mol. These values should be checked against the supplier’s current specification and analytical documentation before use in a regulated or process-critical project. Because physical form, assay, residual solvents, and stability can vary by manufacturing route and lot, buyers should request lot-specific information.

Key Takeaways

• 4-Benzyloxy-2-methylphenylboronic acid is an aryl boronic acid intermediate with CAS 847560-49-0.
• Its principal synthetic relevance is its potential use in palladium-catalyzed Suzuki–Miyaura coupling and related research chemistry.
• The benzyloxy group may serve as a protected phenolic functionality in a multistep synthesis, subject to route-specific conditions.
• Buyers should confirm assay, identity, water, residual solvents, physical form, packaging, and lot documentation before purchase.
• Maison Chemical can support inquiry review, specification alignment, sample evaluation, and commercial supply planning.

What Is 4-Benzyloxy-2-methylphenylboronic Acid?

This molecule belongs to the family of aryl boronic acids, which contain an aromatic carbon bonded to a boronic acid group. In this structure, the aromatic ring also contains a methyl group and a benzyloxy group, creating a specific substitution pattern that can be important when a synthesis requires positional control. The CAS number helps distinguish this compound from related boronic acids with similar names or different substituent locations.

The molecular formula and calculated molecular weight are useful for material identification, stoichiometric calculations, and analytical method development. However, formula information alone does not establish commercial quality, purity, or suitability for a particular reaction. I recommend comparing the supplier’s certificate of analysis, chromatographic data, and analytical method with the requirements of the target process.

Core Functions in Organic Synthesis

Suzuki–Miyaura Coupling Building Block

The boronic acid functionality can act as a coupling partner with a suitable aryl or vinyl halide under appropriate Suzuki–Miyaura reaction conditions. The resulting carbon–carbon bond can connect this substituted aromatic fragment to another molecular segment. Actual conversion depends on the catalyst, base, solvent, temperature, substrate compatibility, and work-up method, so the compound should be treated as a route-specific intermediate rather than a guaranteed plug-and-play reagent.

Protected Phenolic Equivalent

The benzyloxy substituent can be viewed as a benzyl-protected oxygen functionality in suitable synthetic routes. Chemists may later investigate deprotection to reveal a phenolic group, but the feasibility and selectivity of that step depend on the complete molecular structure and the other functional groups present. We therefore advise buyers to evaluate deprotection conditions during route development instead of assuming that one standard method will suit every application.

Potential Application Scenarios

Research organizations may evaluate this intermediate for pharmaceutical discovery, medicinal chemistry, agrochemical research, and the preparation of specialty aromatic compounds. It may be useful when a project requires both a boronic acid handle for coupling and a benzyloxy-substituted methylphenyl fragment. Its value is therefore linked to the target molecule and synthetic sequence rather than to a single universal end use.

In a discovery program, a small quantity may be used for reaction screening, analog synthesis, or route feasibility work. In process development, the focus typically shifts toward batch consistency, impurity control, scalability, and supply continuity. For commercial planning, buyers should also assess whether the supplier can maintain the required specification across multiple lots.

Material and Supply Options

Commercial inquiries may involve laboratory samples, research-grade material, or larger custom quantities. These categories do not automatically represent different chemical identities; they usually reflect different quantity, documentation, packaging, and quality-control requirements. We can review the intended use and help determine whether a standard specification or a project-specific specification is more appropriate.

Buyers should also clarify whether they need the free boronic acid only or whether a different protected or derivative form is acceptable. A related boronate ester is not interchangeable in every procedure, even though it may serve a similar strategic purpose. Any substitution should be confirmed by the project chemist and evaluated experimentally.

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Key Specifications to Confirm

A practical specification review begins with identity. The purchasing file should identify the chemical name, CAS 847560-49-0, molecular formula, calculated molecular weight of approximately 242.08 g/mol, and the analytical techniques used for confirmation, such as NMR, mass spectrometry, or chromatography where appropriate.

For an internal purchasing example, a buyer might request an assay specification of not less than 98.0%, but that figure is an example of a buyer-defined requirement and is not a claim about every lot of this product. Similarly, a project may set a water limit in %, or a residual-solvent limit in ppm, after considering reaction sensitivity and downstream requirements. The correct limits should be agreed before quotation and documented in the commercial specification.

How Buyers Should Select a Supplier

Evaluate Technical Fit First

Start by giving the supplier the intended reaction, estimated annual or project quantity, required assay, and any critical impurity limits. This information allows the supplier to distinguish a simple catalog inquiry from a route-sensitive development requirement. It also helps prevent a low-cost material from being selected without considering analytical or process needs.

Review Documentation and Lot Control

Ask whether the supplier can provide a current certificate of analysis, safety data sheet, batch information, and suitable packaging details. If the material will be used in a multi-step synthesis, compare data from more than one lot when consistency is important. Buyers should avoid treating a single analytical result as proof of long-term supply performance.

Confirm Logistics and Communication

Quantity, destination, import requirements, packaging, and required delivery window can all influence the final sourcing plan. Storage and transport conditions should follow the applicable SDS and supplier guidance because stability can depend on temperature, moisture, light, and container closure. We recommend confirming these details in writing before issuing a purchase order.

How Maison Chemical Supports B2B Sourcing

At Maison Chemical, we approach 4-Benzyloxy-2-methylphenylboronic acid as a specification-led chemical supply project. We can review the requested CAS number, quantity, assay target, documentation needs, packaging preference, and destination before preparing a quotation. Where a standard product does not fully match the application, we can discuss whether custom sourcing or a tailored quality review is appropriate.

Our support can include inquiry clarification, document coordination, sample or batch discussion, export-order communication, and supply planning. We do not replace the buyer’s technical validation, but we aim to make that validation more efficient by organizing the information needed for a practical purchasing decision. Availability, lead time, MOQ, and final commercial terms should be confirmed for each inquiry.

Conclusion: Is This the Right Intermediate for Your Project?

4-Benzyloxy-2-methylphenylboronic acid CAS 847560-49-0 is a specialized aryl boronic acid building block for synthetic research, particularly where a substituted aromatic fragment and a boronic acid coupling handle are both required. Its potential use in Suzuki–Miyaura chemistry and its benzyloxy functionality make it relevant to multistep medicinal, pharmaceutical, agrochemical, and specialty chemical synthesis. Suitability still depends on the complete route and the required quality profile.

The next step is to define your target assay, analytical documentation, quantity, packaging, and delivery requirements. Send Maison Chemical your project specification or purchase inquiry, and we can help review the supply requirements for 4-Benzyloxy-2-methylphenylboronic acid before quotation and procurement.

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